Stadium: Villanova Stadium Round: 1
Home Manager: Mark Ferrante Away Manager: Bob Chesney
| NCAA Division I, FCS, Playoffs | 2021/11/27 17:00 | Sacred Heart Pion. v Holy Cross | W | 10-13 |
| NCAA Division I, FCS, Playoffs | 2021/11/20 18:00 | Holy Cross v Bucknell | W | 45-6 |
| NCAA Division I, FCS, Playoffs | 2021/11/13 18:00 | Holy Cross v Fordham | W | 52-24 |
| NCAA Division I, FCS, Playoffs | 2021/11/06 16:30 | Lafayette v Holy Cross | W | 10-35 |
| NCAA Division I, FCS, Playoffs | 2021/10/30 16:00 | Holy Cross v 레하이 마운틴 호크스 | W | 31-12 |
| NCAA Division I, FCS, Playoffs | 2021/10/23 21:00 | 콜게이트 레이뎌즈 v Holy Cross | W | 10-42 |
| NCAA Division I, FCS, Playoffs | 2021/10/16 17:30 | Georgetown Hoyas v Holy Cross | W | 14-48 |
| NCAA Division I, FCS, Playoffs | 2021/10/02 17:30 | Harvard Crimson v Holy Cross | L | 38-13 |
| NCAA Division I, FCS, Playoffs | 2021/11/20 18:00 | 빌라노바 와일드캣츠 v 댈라웨어 블루 헨즈 | W | 21-13 |
| NCAA Division I, FCS, Playoffs | 2021/11/13 18:00 | 스토니 브룩 시월브즈 v 빌라노바 와일드캣츠 | W | 14-33 |
| NCAA Division I, FCS, Playoffs | 2021/11/06 18:00 | 빌라노바 와일드캣츠 v Elon | W | 35-0 |
| NCAA Division I, FCS, Playoffs | 2021/10/30 17:00 | 윌리엄 & 매리 트라이브 v 빌라노바 와일드캣츠 | L | 31-18 |
| NCAA Division I, FCS, Playoffs | 2021/10/23 19:30 | Rhode Island v 빌라노바 와일드캣츠 | W | 0-44 |
| NCAA Division I, FCS, Playoffs | 2021/10/16 19:30 | 빌라노바 와일드캣츠 v Albany | W | 17-10 |
| NCAA Division I, FCS, Playoffs | 2021/10/09 18:00 | 빌라노바 와일드캣츠 v James Madison | W | 28-27 |
| NCAA Division I, FCS, Playoffs | 2021/09/25 16:00 | 빌라노바 와일드캣츠 v Penn State | L | 17-38 |