Round: 16
| El Salvador Reserves League | 2022/02/06 18:00 | Once Deportivo de Ahuachapán Reserves v AD Isidro Metapan Reserves | D | 2-2 |
| El Salvador Reserves League | 2021/11/18 17:00 | Once Deportivo de Ahuachapán Reserves v AD Isidro Metapan Reserves | L | 3-1 |
| El Salvador Reserves League | 2021/09/16 21:00 | AD Isidro Metapan Reserves v Once Deportivo de Ahuachapán Reserves | D | 2-2 |
| El Salvador Reserves League | 2021/03/10 18:30 | Once Deportivo de Ahuachapán Reserves v AD Isidro Metapan Reserves | D | 1-1 |
| El Salvador Reserves League | 2021/02/18 18:45 | AD Isidro Metapan Reserves v Once Deportivo de Ahuachapán Reserves | W | 4-1 |
| El Salvador Reserves League | 2020/02/26 18:02 | Once Deportivo de Ahuachapán Reserves v AD Isidro Metapan Reserves | W | 2-3 |
| El Salvador Reserves League | 2022/04/03 17:00 | CD Platense Zacatecoluca Reserves v AD Isidro Metapan Reserves | L | 3-2 |
| El Salvador Reserves League | 2022/03/23 21:00 | AD Isidro Metapan Reserves v CD Luis Angel Firpo Reserves | W | 2-1 |
| El Salvador Reserves League | 2022/03/19 21:00 | AD Chalatenago Reserves v AD Isidro Metapan Reserves | D | 2-2 |
| El Salvador Reserves League | 2022/03/12 21:00 | AD Isidro Metapan Reserves v Alianza FC San Salvador Reserves | L | 1-3 |
| El Salvador Reserves League | 2022/03/05 17:00 | Atletico Marte Reserves v AD Isidro Metapan Reserves | W | 1-3 |
| El Salvador Reserves League | 2022/02/26 21:00 | AD Isidro Metapan Reserves v Municipal Limeno Reserves | L | 0-1 |
| El Salvador Reserves League | 2022/02/23 21:30 | Santa Tecla Reserves v AD Isidro Metapan Reserves | L | 5-2 |
| El Salvador Reserves League | 2022/02/19 21:00 | AD Isidro Metapan Reserves v CD FAS Reserves | W | 1-0 |
| El Salvador Reserves League | 2022/04/03 17:00 | Once Deportivo de Ahuachapán Reserves v Atletico Marte Reserves | W | 1-0 |
| El Salvador Reserves League | 2022/03/25 18:00 | Municipal Limeno Reserves v Once Deportivo de Ahuachapán Reserves | D | 1-1 |
| El Salvador Reserves League | 2022/03/19 18:30 | Once Deportivo de Ahuachapán Reserves v Santa Tecla Reserves | D | 0-0 |
| El Salvador Reserves League | 2022/03/05 18:30 | Jocoro FC Reserves v Once Deportivo de Ahuachapán Reserves | W | 1-2 |
| El Salvador Reserves League | 2022/02/27 17:00 | Once Deportivo de Ahuachapán Reserves v CD Aguila Reserves | D | 1-1 |
| El Salvador Reserves League | 2022/02/23 17:00 | Once Deportivo de Ahuachapán Reserves v Alianza FC San Salvador Reserves | D | 1-1 |
| El Salvador Reserves League | 2022/02/20 17:00 | CD Platense Zacatecoluca Reserves v Once Deportivo de Ahuachapán Reserves | L | 3-2 |
| El Salvador Reserves League | 2022/02/13 18:00 | Once Deportivo de Ahuachapán Reserves v CD Luis Angel Firpo Reserves | L | 0-1 |