| ITF W75 Chiasso | 04/17 12:30 | 25 | [235] 파파미차일, 데스피나 v Popa, Maria Sara [432] | 7-5,5-7,6-7 | |
| Billie Jean King Cup 2022, Finals | 04/09 10:00 | 1 | [111] 크루니크, 알렉산드라 v 파파미차일, 데스피나 [235] | 6-0,6-3 | |
| Billie Jean King Cup 2022, Finals | 04/08 09:50 | 1 | [469] 리날도 페르슨, 카이사 v 파파미차일, 데스피나 [235] | 4-6,4-6 | |
| ITF W35 Santa Margherita | 04/03 07:25 | 25 | [245] 파파미차일, 데스피나 v Cherubini, Diletta [412] | 2-6,7-6,4-6 | |
| ITF W35 Terrassa | 03/29 09:30 | 28 | [260] 파파미차일, 데스피나 v 보이손, 로이스 [293] | 3-6,6-0,1-6 | |
| ITF W35 Terrassa | 03/28 09:00 | 27 | [467] 헤네만, 카이사 윌다 v 파파미차일, 데스피나 [260] | 1-6,6-3,4-6 | |
| ITF W35 Terrassa | 03/27 08:55 | 26 | [385] 기오로아이, 일로나 게오르지아나 v 파파미차일, 데스피나 [260] | 4-6,5-7 | |
| ITF W35 Terrassa | 03/26 14:35 | 25 | Dols, Sara v 파파미차일, 데스피나 | 2-6,3-6 | |
| ITF W35 Alaminos-Larnaca | 03/24 09:00 | 29 | [293] 보이손, 로이스 v 파파미차일, 데스피나 [260] | 6-2,6-0 | |
| ITF W35 Alaminos-Larnaca | 03/23 08:00 | 28 | [260] 파파미차일, 데스피나 v 치에사, 데보라 [460] | 4-6,6-3,6-3 | |
| ITF W35 Alaminos-Larnaca | 03/22 08:00 | 27 | [214] 미투, 크리스티나-안드레아 v 파파미차일, 데스피나 [260] | 2-6,0-6 | |
| ITF W35 Alaminos-Larnaca | 03/21 07:30 | 26 | [260] 파파미차일, 데스피나 v 루카스, 테나 [203] | 4-6,6-2,6-1 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.